In this episode, Dr. Nick Fogelson and Dr. Shanti Mohling take on one of the most persistent gray zones in gynecology: how to safely use hormone replacement therapy in patients with current or past endometriosis. Moving beyond the simplistic “estrogen bad” narrative, they explore what the data actually show about recurrence, cancer risk, and quality of life. The discussion weaves clinical insight with case studies, examining how progesterone’s protective role, surgical completeness, and individualized dosing all shape outcomes. Highlights: The lingering misconceptions from the Women’s Health Initiative study and what modern research now shows about the safety of hormone replacement. Why bioidentical progesterone should often accompany estrogen—even in hysterectomized patients with prior endometriosis. Real-world case studies revealing how residual disease and incomplete excision affect postmenopausal pain and risk. The broader benefits of HRT—stronger bones, cardiovascular protection, cognitive support—and how fear-based medicine often obscures them. Updates from the surgical front: robotic excision of endometriosis in outpatient centers, plus a preview of the next episode on MyReceptiva’s diagnostic test for endometriosis. For clinical consultations: contact Northwest Endometriosis and Pelvic Surgery in Portland, OR at (503) 715-1377 or email us at [email protected]  Follow us on Instagram: @Nicholasfogelson and @drshantimohling   Download a transcript of this episode.    

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