Episode Synopsis "Difluorinated Alkyl Bromide Synthesis via Chiral Iodoarene Catalysis"

In this episode we discuss a report from the Jacobsen lab on an enantioselective synthesis of difluorinated alkyl bromides catalyzed by a chiral iodoarene. Linear free energy relationships between experimental enantioselectivities and computed catalyst parameters helped elucidate the origins of enantioselectivity.  DOI: 10.1021/jacs.0c07043

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• Trailer