In this episode of the College of Glycation series, Dr. Paul Reynolds explores how sugar-driven damage in the form of advanced glycation end products (AGEs) accelerates brain aging and contributes to Alzheimer’s, Parkinson’s, depression, and other mental health challenges. He breaks down the science of glycation and insulin resistance, showing how they disrupt brain function, fuel inflammation, and create what many researchers call “Type 3 Diabetes.”Drawing from cutting-edge research and clinical insights, Dr. Reynolds highlights why standard treatments often fall short and how nutrition—particularly ketogenic therapies and low-AGE diets—can protect and even restore brain health. Packed with practical strategies and science-backed guidance, this conversation equips listeners with the tools to reduce glycation, support cognitive performance, and take control of long-term brain health.

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