Your gut is talking — and your brain is listening. Discover how diet, microbiota, and even fasting reshape your brain chemistry, mood, and cognition in this deep dive into the gut-brain connection.Your gut is talking to your brain — and your brain is listening. In this episode of The Cognitive Performer, we explore the gut-brain axis — the communication highway connecting your digestive system and your mind. Discover how trillions of microorganisms influence your mood, focus, memory, and long-term brain health. We’ll look at how diet shapes your microbiome, why certain bacteria can act like microscopic pharmacists, and what dietary patterns best protect cognitive function. From the serotonin-shaping power of Roseburia intestinalis to the fasting-linked boost in microglial cleanup, this episode unpacks the real neuroscience behind “gut feelings.”Key TakeawaysRoughly 90 % of the vagus-nerve signals run from gut → brain, not the other way around.The gut microbiome produces neurotransmitters such as serotonin, dopamine, and GABA that directly influence mood and cognition.Stress diverts tryptophan from serotonin production toward inflammation — but beneficial bacteria can reverse that shift.Mediterranean, DASH, and MIND diets consistently support brain health by nourishing diverse gut bacteria.Alternate-day fasting reshapes gut microbes and improves microglial function, translating into measurable cognitive gains.Building cognitive reserve through learning, social connection, movement, and sleep can cut dementia risk nearly in half.Links and ResourcesQu S et al. (2024). Gut microbiota modulates neurotransmitter and gut-brain signaling. Microbiological Research, 287.Zhou M. F. et al. (2023). Microbiome and the kynurenine metabolic pathway in depression. Microbiome, 11.Gong Y et al. (2025). Healthy dietary patterns and cognitive performance. J. Prev. Alzheimer’s Dis., 12.Mela V et al. (2025). Microbiota fasting-related changes ameliorate cognitive decline in obesity. Gut.Ward N A et al. (2023). PROMED-EX Randomised Controlled Trial. BMJ Open, 13.Bekdash R A (2024). Epigenetics, Nutrition, and the Brain. Int. J. Mol. Sci., 25.Margolis K G et al. (2021). Microbiota-gut-brain axis modulation of enteric and central nervous system function. Gastroenterology, 160.Cryan J F et al. (2021). Diet, microbiota, and host behavior — narrative review. Adv. Nutrition.Connect and SubscribeFor more neuroscience-backed insights on performance, mindset, and mental health, subscribe to The Cognitive Performer Newsletter at thecognitiveperformer.com.

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