Ulcerative Colitis (UC) & Crohn's Disease (CD) are chronic Inflammatory Bowel Diseases that have significant effects on patients. They are notoriously hard to treat due to (but not limited to) the following reasons:Chronic and Relapsing Nature: Both UC and CD are chronic diseases that can have unpredictable and relapsing symptoms, making it difficult to maintain long-term control of the condition.The complexity of the disease: The underlying mechanisms that cause UC and CD are not fully understood, and the diseases can affect different parts of the digestive tract in different ways, making it challenging to develop a one-size-fits-all treatment approach.Inter-patient heterogeneity: People with UC and CD can have varying symptoms and respond differently to treatments, making it difficult to determine the most effective approach for each individual.Side Effects of Medications: The medications used to treat UC and CD can have side effects and may not be effective for everyone. In some cases, long-term use of these medications can also lead to additional health problems.Dr. Azucena Salas is a collaborator with Dr. Holger Heyn and they released a pre-print on investigating Inflammatory Bowel Disease with both sc-RNA-Seq and the CosMx SMI. We discuss the difficulties in treatment, interpatient heterogeneity, and the discovery of different macrophage populations which seem to add to that heterogeneity and variation in phenotype.This podcast includes information regarding worldwide products and services, not all of which are available in every country.

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