Welcome back to Rad Onc Smart Review! This is Episode 34: DNA Damage Sensing & Signaling: ATM, ATR, and γH2AX. Today, we're diving deep into the cell's intricate emergency response system, the DNA Damage Response, or DDR. We'll explore how cells detect various types of DNA damage, particularly the highly cytotoxic double-strand breaks (DSBs) and replication stress, and how a sophisticated network of sensor, transducer, and effector proteins orchestrates cell cycle checkpoints, DNA repair, and sometimes, apoptosis. We'll meticulously unpack the roles of master kinases ATM and ATR, the initial damage sensing by the MRN complex, the crucial modification of H2AX to γH2AX, and the activation of downstream checkpoint kinases CHK1 and CHK2, all vital for maintaining genomic integrity and highly relevant for your board exams.

Ver todos los episodios