Welcome back to Rad Onc Smart Review! Rad Bio Edition! Today we’re exploring a very hot topic in cancer therapy: the intersection of radiation and the immune system. This is Episode 33: Cancer Immunology & Radiation Synergy. For a long time, radiation was thought of primarily as a local, directly cytotoxic treatment. But we now understand that radiation doesn't just kill cancer cells; it can profoundly modulate the immune system and the tumor microenvironment. We'll discuss how radiation can sometimes turn a "cold" tumor "hot," making it more visible to the immune system, and how this understanding is paving the way for powerful combination therapies, especially with immune checkpoint inhibitors.

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