In our last episodes, we drilled down into how cells repair specific DNA lesions, like base damage, single-strand breaks, and those critical double-strand breaks via NHEJ and HR. Today, we're zooming out to look at the bigger picture: what happens when DNA breaks lead to large-scale damage visible at the chromosome level? We'll cover different types of chromosome aberrations caused by radiation, classifying them as lethal or potentially cancer-promoting, and link these concepts to human genetic syndromes caused by defects in DNA repair.

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