This is Episode 25: Radioprotectors & Hyperthermia.In our previous discussions, we've explored ways to make tumor cells more vulnerable to radiation, particularly focusing on the challenge of hypoxia. Today, we're flipping the script slightly and also looking at strategies to enhance radiation’s effectiveness in different ways. First, we'll delve into radioprotectors, specifically compounds like Amifostine, which aim to shield our healthy normal tissues from radiation damage, potentially widening that all-important therapeutic window. Then, we'll turn up the heat and discuss hyperthermia – how using elevated temperatures can sensitize cancer cells to radiation, its biological effects, and the mechanisms like thermotolerance and heat shock proteins that come into play.

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