This is Episode 18, Part C: Fractionation - The LQ Model, BED, and Isoeffect Curves.In our previous discussions on fractionation, we’ve explored the "4 R's" and the impact of dose rate. These concepts help explain why fractionated radiotherapy works. Now, we need a way to quantify these effects and compare different fractionation schedules. This is where the Linear-Quadratic, or LQ, model comes into play. Today, we'll revisit the LQ model, delve deep into the meaning of the α/β ratio, and learn how to use it to calculate the Biological Effective Dose (BED) and Equivalent Dose in 2 Gy fractions (EQD2). We'll also learn to interpret isoeffect curves, which visually represent how different tissues respond to changes in fractionation. And finally, we’ll briefly touch upon some of the limitations of this widely used model.

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