Welcome back to Rad Onc Smart Review, your go-to podcast for mastering the core concepts of radiation oncology and radiobiology. This is Episode 12 Part B, Tumor Kinetics - Tpot, GF & Cell Loss. In our previous episode, P12a, we laid the groundwork by exploring the phases of the cell cycle, how radiosensitivity varies within them, and the techniques used to measure cell cycle parameters, like Percent Labeled Mitoses and Flow Cytometry. Today, we're going to build directly on that knowledge to understand the growth dynamics of tumors themselves. We'll define key kinetic parameters such as Labeling Index, Potential Doubling Time or Tpot, Growth Fraction, and the crucial Cell Loss Factor, and discuss how these factors, including accelerated repopulation, influence tumor growth and response to therapy.

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