If there is one disease site that perfectly illustrates the power of multidisciplinary, evidence-based cancer care, it’s rectal cancer. The evolution of its treatment is a masterclass in how surgery, radiation, and chemotherapy can be integrated to dramatically improve outcomes. But before we can appreciate that evolution, we must master the fundamentals.Today, we lay the groundwork for this entire story. We will use a classic case to walk through the essential workup, the critical anatomy that dictates treatment, modern staging with MRI, and finally, the surgical innovation that changed everything—Total Mesorectal Excision.

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