Brain metastases are the most common intracranial tumor in adults, and their management has undergone a complete revolution. Before we can treat, we must be able to prognosticate and have a firm grasp of the foundational principles. Today, we will cover the essential background, including epidemiology and workup. We will master the modern prognostic indices, including the Disease-Specific Graded Prognostic Assessment, or D-S-G-P-A. And finally, we will open the whole-brain radiotherapy toolkit, discussing the evidence for adding memantine and detailing the technique and landmark data for hippocampal-avoidance WBRT.

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