This is Episode 7: Low-Grade Glioma Part 2: Evidence for Chemo, Dose, and IDH Inhibitors.In our last episode, we established the framework for managing Grade II gliomas, answering the crucial question of when to treat. Today, we address the next logical question: for those high-risk patients we decide to treat, how do we treat them? We will dissect the pivotal evidence that transformed our approach from radiation alone to combined-modality therapy, justify our standard radiation dose by looking at the specific data from the negative dose-escalation trials, and look to the future with the exciting new data on targeted IDH inhibitors.

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