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Listen "CNS E02: High-Grade Glioma Part 2: Anaplastic Astrocytoma and the Rise of Molecular Grade 4"
Episode Synopsis
In our last episode, we established the modern molecular framework for diagnosing high-grade gliomas and detailed the management of anaplastic oligodendroglioma. Today, we explore the other side of that coin. We will master the management of anaplastic astrocytoma by dissecting the pivotal CATNON trial, and we’ll tackle a challenging new entity introduced in the 2021 WHO classification: the IDH-mutant astrocytoma, Grade 4, a tumor that looks lower-grade under the microscope but carries a much graver prognosis based on its genetics.
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