Biochemistry | Alcohol Metabolism

21/12/2025 16 min Episodio 86
Biochemistry | Alcohol Metabolism

Listen "Biochemistry | Alcohol Metabolism"

Episode Synopsis

🍐 In this episode of PodBites, Omar Luay and Abdallah Kharsa break down alcohol metabolism — following ethanol from absorption to breakdown, and explaining why this everyday substance causes such wide-ranging clinical effects.
🎙️ Tune in to explore:


How alcohol is absorbed, distributed, and eliminated


The two-step breakdown: ADH → acetaldehyde → ALDH


Why acetaldehyde causes flushing and hangover symptoms


The role of NADH excess in lactic acidosis and hypoglycemia


MEOS (CYP2E1) and drug–alcohol interactions


Genetic differences behind Asian flush syndrome


Chronic alcohol complications: fatty liver, cirrhosis, and neurotoxicity


Key clinical ties like thiamine deficiency and disulfiram


🌟 A high-yield, clinic-linked breakdown that turns alcohol metabolism from trivia into something you can actually reason through.