This week's episode recaps some highlights from ESMO 2025:

1. Destiny-Breast05: T-DXd > T-DM1 in persistent HER2+ disease after neoadjuvant chemo + surgery
2. Keynote-905: Neoadjuvant Enfortumab Vedotin + pembro in cisplatin-ineligible bladder cancer
3. POTOMAC: Durvalumab + BCG in non-muscle invasive bladder cancer
4. IMvigor011: ctDNA-guided adjuvant atezolizumab in bladder cancer
5. Dynamic-III: ctDNA guide de-escalation or escalation of chemotherapy in stage III colon cancer
6. HARMONi-6: an excuse to talk about ivonescimab, a bispecific antibody unlike any other currently FDA approved

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