DPYD Variant Dosing & ICIs In Pancreatic Cancer

31/08/2023 19 min
DPYD Variant Dosing & ICIs In Pancreatic Cancer

Listen "DPYD Variant Dosing & ICIs In Pancreatic Cancer"

Episode Synopsis

Empiric dose reductions for variant DPYD alleles isn't necessarily new, but the outcomes of patients treated with those dose reductions isn't well described. Dutch researchers provide some much needed evidence.
Link: https://pubmed.ncbi.nlm.nih.gov/?term=37639651

Is there a role for ICIs in dMMR/MSI-h pancreatic cancer? This retrospective says, uh maybe probably.
Link: https://pubmed.ncbi.nlm.nih.gov/?term=37625102