Obesity is a disease that patients “wear” on the outside of their bodies, making it unlike most other medical conditions. And…Physicians could never have imagined a time when patients came into the office asking them for medications. Shockingly... the era of weight loss medications (GLP1s, semaglutide, tirzepatide) has ushered in one of the biggest philosophical shifts in medicine, with both patients and physicians, completely changing their approach to weight management.  In this culturally-relevant episode of HeART of Medicine, Drs. Kohli and Jazaeri discuss how this class of medications called GLP-1RAs has revolutionized medicine, creating an identity shift in how we think about prevention and medical care. In addition, they also discuss the impacts of GLP1s on the patient-doctor relationship, the impacts of these medications (which over 40% of the country qualifies for) on the healthcare system, their impact on cardiovascular outcomes and even on the culture and perception of obesity.This is definitely an episode of HeART of Medicine that almost all of us can relate to as we have all been front-row witnesses to the rise of the era of weight-loss medications, a shift that has changed medicine forever and will go down in the history books.

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