The importance of O Antiphons is twofold: Each one highlights a title for the Messiah: O Sapientia (O Wisdom), O Adonai (O Lord), O Radix Jesse (O Root of Jesse), O Clavis David (O Key of David), O Oriens (O Rising Sun), O Rex Gentium (O King of the Nations), and O Emmanuel. Also, each one refers to the prophecy of Isaiah of the coming of the Messiah. Lets now look at each antiphon with just a sample of Isaiahs related prophecies :

O Sapientia: O Wisdom, O holy Word of God, you govern all creation with your strong yet tender care. Come and show your people the way to salvation. Isaiah had prophesied, The spirit of the Lord shall rest upon him: a spirit of wisdom and of understanding, a spirit of counsel and of strength, a spirit of knowledge and fear of the Lord, and his delight shall be the fear of the Lord. (Isaiah 11:2-3), and Wonderful is His counsel and great is His wisdom. (Isaiah 28:29).

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