The story of rheumatoid factor could be a 10 minute episode, but in this episode, we dig deep into the history of the lab techniques leading up to this discovery…that happened twice.  ·        Intro 0:04 ·        Rheumatoid factor quick background and history 00:22 ·        Rheumatology blood tests 2:47 ·        What is Rheumatoid factor? 3:39 ·        Spiderman and latex agglutination: Testing for rheumatoid factor 4:49 ·         4:54 ·        The double discovery of rheumatoid factor 7:52 ·        Putting agglutination on the medical map in 1896 10:03 ·        Pop Quiz! 11:04 ·        Serotherapy 13:00 ·        When did we start using agglutination for testing? 14:07 ·        First discovery of blood groups 14:44 ·        The complement fixation test 17:12 ·        Testing for syphilis with complement fixation and agglutination 20:53 ·        The first discovery of rheumatoid factor 24:02 ·        We forget about rheumatoid factor 27:48 ·        Rediscovering rheumatoid factor 28:20 ·        Analytical ultracentrifugation 32:55 ·        What rheumatoid factor is used for 35:50 ·        Thanks for listening 38:09   We'd love to hear from you! Send your comments/questions to Dr. Brown at [email protected]. Follow us on Twitter @HRheuminations @AdamJBrownMD @HealioRheum. References: Assadian O et al. Wien Klin Wochenschr. 2010;doi:10.1007/s00508-009-1297-1 Edelman GM, et al. J Exp Med. 1958;doi:10.1084/jem.108.1.105 Franklin EC, et al. J Exp Med. 1957;doi:10.1084/jem.105.5.425 Fraser KJ. Semin Arthritis Rheum. 1988;doi:10.1016/0049-0172(88)90035-2 Jonsson R. Ann Rheum Dis. 2020;doi:10.1136/annrheumdis-2019-216822 Mohd Noor NH, et al. Cureus. 2024;doi:10.7759/cureus.68903 Tan EM, et al. J Exp Med. 2016;doi:10.1084/jem.20160792 Disclosures: Brown reports no relevant financial disclosures.

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