For decades, people suffering from chronic depression have relied on medicines that affect the levels of chemicals in the brain like serotonin, which regulate mood and emotion. But ten percent of people don’t benefit from any of the existing treatments for this devastating condition. Sisters Annie and Kathryn have both been diagnosed with long-term depression that makes it hard for them to experience pleasure as others do. But they’re interested in whether there are new solutions on the horizon that could improve their wellbeing, in particular ones that don’t necessarily involve conventional medication. Datshiane Navanayagam learns how a technique called mindfulness could strengthen neural connections in bits of the brain that communicate with each other. This, it’s said, may harness the ability of the brain to adapt and self-repair which can change people’s emotional responses to life’s ups and downs. She meets a psychologist who shows how this simple technique could improve our overall ability to process information and reverse negative thought patterns.CrowdScience also hears about cutting edge research into the use of psychedelics as potential treatment for depression and heads to the UK’s only centre for ketamine therapy, where patients say a drug once popular with partygoers, is having a profound effect on their mental health.Produced by Marijke Peters for BBC World Service.(Photo: A woman sitting on the top of a mountain and meditating. Credit: Getty Images)

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