On today's episode, we chat with Dr. Sheldon Cheskes, principal investigator of the landmark DOSE VF trial.  In this study, published in the New England Journal of Medicine, Dr. Cheskes and his team wanted to evaluate DSED and VC defibrillation as compared with standard defibrillation in patients who remain in refractory ventricular fibrillation during out-of-hospital cardiac arrest. In this episode, we walk through the study design, methodology, results, and perhaps most importantly, critically appraise the study to see how it works in the real world! Timestamps: 02:48: Dr. Cheskes Intro 06:15: Study Intro 16:45: Patients 18:18: Intervention – Vector Change 25:45: Intervention – DSED 37:12: Comparison/Outcome 40:23: Results 54:15: Critical Appraisal

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