Episode Description:

Episode Overview

In this episode of Frontiers of Research, host Antoni explores the revolutionary field of CRISPR epigenome editing with experts Dr. Sarah Chen and Dr. Josh Patel. They discuss how CRISPR technology is being adapted to modify epigenetic marks without changing the underlying DNA sequence, opening new possibilities for treating genetic diseases and understanding gene regulation.

Key Topics


The evolution of CRISPR from DNA editing to epigenome modification
dCas9 and other catalytically inactive Cas proteins for targeted epigenetic editing
Applications in treating genetic diseases through epigenetic reprogramming
Challenges in achieving precise and reversible epigenetic modifications
Current clinical trials and therapeutic potential
Future directions in epigenome editing technology


Why It Matters

CRISPR epigenome editing represents a paradigm shift in genetic medicine, offering the potential to treat diseases by modifying gene expression rather than changing DNA sequences. This approach could provide reversible treatments for a wide range of conditions while avoiding the permanent alterations associated with traditional gene editing.

References


Liao, H.K., Hatanaka, F., Araoka, T., Reddy, P., Wu, M.Z., Sui, Y., Yamauchi, T., Sakurai, M., O'Keefe, D.D., Nunez-Delicado, E., et al. (2017). In vivo Target Gene Activation via CRISPR/Cas9-Mediated Trans-epigenetic Modulation. Cell. https://doi.org/10.1016/j.cell.2017.01.038
Liu, X.S., Wu, H., Ji, X., Stelzer, Y., Wu, X., Czauderna, S., Shu, J., Dadon, D., Young, R.A., Jaenisch, R. (2016). Editing DNA Methylation in the Mammalian Genome. Cell. https://doi.org/10.1016/j.cell.2016.09.049


Hashtags

CRISPR #Epigenetics #GeneTherapy #GeneticEngineering #Biotechnology #MolecularBiology #GeneExpression #EpigenomeEditing #GeneticMedicine #BiomedicalResearch #TherapeuticDevelopment #PrecisionMedicine #GeneRegulation #ChromatinModification #EpigeneticReprogramming #Biology #Genetics #CRISPR #Epigenetics #PrecisionMedicine #Science

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