Pour the coffee and buckle in—this is Part 2 of our cancer deep dive. If you missed Part 1, we tackled the cell-level chaos: oncogenes (the gas pedal), tumor suppressors (the brakes), caretaker genes (the pit crew), and the full “hallmarks of cancer” bingo card. Now, Poppy and Kae zoom out from the microscope to the big picture, following along with McCance & Huether’s Pathophysiology, 9th Edition (Chapters 12–14).We start with cancer epidemiology—where genes collide with lifestyle and environment. Tobacco, diet, obesity, alcohol, radiation, infections, and even workplace exposures all get their moment in the spotlight. Spoiler: cancer isn’t just “bad luck DNA.” Then we step into pediatric oncology, where kids are not just small adults: think leukemias, sarcomas, blastomas, and the genetic syndromes that change the game. Finally, we pull threads into the clinical world with paraneoplastic syndromes, cachexia, TNM staging, tumor markers, and multimodal treatments—and put it all into practice with an SBAR handoff.Expect board-worthy mnemonics, chaos metaphors, and at least one Oprah reference (“you get a cancer, you get a cancer”). By the end, you’ll not only have the exam-ready facts, but also the big-picture nursing lens to connect biology, risk, and bedside practice.Because cancer isn’t just a diagnosis—it’s a rebellion of cells, environments, and choices. And as nurses, knowing the why makes us better at spotting the what.

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