Targeting the Fc Receptor Pathway to Treat Red Blood Cell Alloimmunization

27/10/2022 13 min

Listen "Targeting the Fc Receptor Pathway to Treat Red Blood Cell Alloimmunization "

Episode Synopsis



Host: Lee P. Shulman, MD, FACMG, FACOG

Guest: Kenneth J. Moise Jr., MD



This program is no longer available for credit. Program Chairman:Roberto Romero, MD, DMedSciChief, Perinatology Research BranchDivision of Maternal-Fetal Medicine and ObstetricsDivision of Intramural ResearchNICHD/NIH/DHHSEditor-in-Chief for ObstetricsThe American Journal of Obstetrics and Gynecology How well do you understand the biology of hemolytic disease of the fetus and newborn (HDFN)? What about its connection to the FcRn receptor pathway and IgG? Drs. Lee Shulman and Ken Moise go beyond the basics taught in medical school immunology and look more closely at FcRn’s role in protecting IgG. With an improved understanding of these mechanisms, we can expand therapeutic targets beyond the fetus and newborn and finally put the needles away.

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