The childhood immunization schedule is one of the defining pillars of pediatric practice and remains among the most successful public health achievements of the modern era. Yet, in recent months, the schedule and the systems that support it have faced new challenges, raising serious concerns for pediatricians across the country. This episode was recorded live at the 2025 American Academy of Pediatrics National Conference in Denver, Colorado. In this episode, we discuss the latest AAP vaccine updates and the evolving landscape of childhood immunizations. Sue Kressly, MD, is a general pediatrician as well as the President of the AAP. Sean O'Leary, MD, is a pediatric infectious disease specialist at Children's Colorado and a professor at the University of Colorado School of Medicine. He is also chair of the AAP Committee on Infectious Diseases, otherwise known as the Red Book Committee. Some highlights from this episode include:  The latest AAP immunization guidance and policy updates  Changes currently impacting pediatricians  Insight into the near future of vaccine distributions  Strategies for combatting confusion and shifting vaccine confidence  For more information on Children's Colorado, visit: childrenscolorado.org. 

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