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Listen "Triglycerides Drive Aneurysm Rupture Risk 09/23/25"
Episode Synopsis
Welcome to Cardiology Today – Recorded September 23, 2025. This episode summarizes 5 key cardiology studies on topics like MELOS RELOADED and Pacemaker. Key takeaway: Triglycerides Drive Aneurysm Rupture Risk.
Article Links:
Article 1: Hypertriglyceridemia as a Key Contributor to Abdominal Aortic Aneurysm Development and Rupture: Insights From Genetic and Experimental Models. (Circulation)
Article 2: Left bundle branch area pacing vs right ventricular pacing for atrioventricular block: the MELOS RELOADED study. (European heart journal)
Article 3: Epidemiology and risk factors for constrictive pericarditis in a statewide Australian cohort of patients with pericardial disease. (The Canadian journal of cardiology)
Article 4: Self-Expanding Intra-Annular Transcatheter Aortic Valve Replacement System in Patients with Severely Calcified Aortic Valve. (The Canadian journal of cardiology)
Article 5: Lower interventricular septal thickness from computed tomography predicts the need for pacemaker implantation after TAVR. (International journal of cardiology)
Full episode page: https://podcast.explainheart.com/podcast/triglycerides-drive-aneurysm-rupture-risk-09-23-25/
Featured Articles
Article 1: Hypertriglyceridemia as a Key Contributor to Abdominal Aortic Aneurysm Development and Rupture: Insights From Genetic and Experimental Models.
Journal: Circulation
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40762097
Summary: This study used Mendelian randomization and experimental models to investigate the relationship between triglycerides and abdominal aortic aneurysm. The findings suggest elevated triglyceride levels causally contribute to abdominal aortic aneurysm development and rupture, identifying a potential therapeutic target. This indicates that lowering triglycerides could be a pharmacological strategy to prevent abdominal aortic aneurysm progression.
Article 2: Left bundle branch area pacing vs right ventricular pacing for atrioventricular block: the MELOS RELOADED study.
Journal: European heart journal
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40977097
Summary: The MELOS RELOADED study, a multicenter European registry, compared left bundle branch area pacing to right ventricular pacing in patients with atrioventricular block. Results demonstrated no significant difference in long-term survival between the two pacing strategies. Further analysis is needed to identify subgroups that may benefit more from left bundle branch area pacing.
Article 3: Epidemiology and risk factors for constrictive pericarditis in a statewide Australian cohort of patients with pericardial disease.
Journal: The Canadian journal of cardiology
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40983194
Summary: This retrospective cohort study analyzed hospitalized patients with pericardial disease in New South Wales, Australia, from 2004 to 2021 to identify risk factors for constrictive pericarditis. The study defined the epidemiology and predictors of constrictive pericarditis utilizing multivariable logistic regression to determine risk factors within this large population-based cohort. The results illuminate potential targets for early intervention and prevention of this rare but serious complication.
Article 4: Self-Expanding Intra-Annular Transcatheter Aortic Valve Replacement System in Patients with Severely Calcified Aortic Valve.
Journal: The Canadian journal of cardiology
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40983190
Summary: This retrospective, multicenter study evaluated the impact of severe aortic valve calcification on outcomes following transcatheter aortic valve replacement using self-expanding intra-annular transcatheter heart valves. The study revealed that severe aortic valve calcification does not significantly impact procedural or clinical outcomes in patients undergoing transcatheter aortic valve replacement with Portico or Navitor transcatheter heart valves. This suggests that these valves are safe and effective even in patients with heavily calcified valves.
Article 5: Lower interventricular septal thickness from computed tomography predicts the need for pacemaker implantation after TAVR.
Journal: International journal of cardiology
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40983185
Summary: This study investigated the role of interventricular septal thickness, measured via pre-procedural computed tomography, in predicting the need for permanent pacemaker implantation after transcatheter aortic valve replacement. The findings indicate that lower interventricular septal thickness is a predictor of permanent pacemaker implantation post-transcatheter aortic valve replacement. Integrating interventricular septal thickness into pre-procedural assessment may improve risk stratification and patient selection.
Transcript
Today’s date is September 23, 2025. Welcome to Cardiology Today. Here are the latest research findings.
Article number one. Hypertriglyceridemia as a Key Contributor to Abdominal Aortic Aneurysm Development and Rupture: Insights From Genetic and Experimental Models. This study used Mendelian randomization and experimental models to investigate the relationship between triglycerides and abdominal aortic aneurysm. The findings suggest elevated triglyceride levels causally contribute to abdominal aortic aneurysm development and rupture, identifying a potential therapeutic target. This indicates that lowering triglycerides could be a pharmacological strategy to prevent abdominal aortic aneurysm progression.
Article number two. Left bundle branch area pacing vs right ventricular pacing for atrioventricular block: the MELOS RELOADED study. The MELOS RELOADED study, a multicenter European registry, compared left bundle branch area pacing to right ventricular pacing in patients with atrioventricular block. Results demonstrated no significant difference in long-term survival between the two pacing strategies. Further analysis is needed to identify subgroups that may benefit more from left bundle branch area pacing.
Article number three. Epidemiology and risk factors for constrictive pericarditis in a statewide Australian cohort of patients with pericardial disease. This retrospective cohort study analyzed hospitalized patients with pericardial disease in New South Wales, Australia, from 2004 to 2021 to identify risk factors for constrictive pericarditis. The study defined the epidemiology and predictors of constrictive pericarditis utilizing multivariable logistic regression to determine risk factors within this large population-based cohort. The results illuminate potential targets for early intervention and prevention of this rare but serious complication.
Article number four. Self-Expanding Intra-Annular Transcatheter Aortic Valve Replacement System in Patients with Severely Calcified Aortic Valve. This retrospective, multicenter study evaluated the impact of severe aortic valve calcification on outcomes following transcatheter aortic valve replacement using self-expanding intra-annular transcatheter heart valves. The study revealed that severe aortic valve calcification does not significantly impact procedural or clinical outcomes in patients undergoing transcatheter aortic valve replacement with Portico or Navitor transcatheter heart valves. This suggests that these valves are safe and effective even in patients with heavily calcified valves.
Article number five. Lower interventricular septal thickness from computed tomography predicts the need for pacemaker implantation after TAVR. This study investigated the role of interventricular septal thickness, measured via pre-procedural computed tomography, in predicting the need for permanent pacemaker implantation after transcatheter aortic valve replacement. The findings indicate that lower interventricular septal thickness is a predictor of permanent pacemaker implantation post-transcatheter aortic valve replacement. Integrating interventricular septal thickness into pre-procedural assessment may improve risk stratification and patient selection.
Thank you for listening. Don’t forget to subscribe.
Keywords
MELOS RELOADED, Pacemaker, Left Bundle Branch Area Pacing, Navitor, Epidemiology, Aortic Valve Calcification, Atrioventricular Block, Portico, Computed Tomography, Right Ventricular Pacing, Abdominal Aortic Aneurysm, Hypertriglyceridemia, Self-Expanding Valve, Interventricular Septal Thickness, Transcatheter Aortic Valve Replacement, Permanent Pacemaker Implantation, Mendelian Randomization, Risk Factors, Constrictive Pericarditis, Lipoproteins, Aortic Stenosis, Pericardial Disease.
About
Concise summaries of cardiovascular research for professionals.
Subscribe • Share • FollowThe post Triglycerides Drive Aneurysm Rupture Risk 09/23/25 first appeared on Cardiology Today.
Article Links:
Article 1: Hypertriglyceridemia as a Key Contributor to Abdominal Aortic Aneurysm Development and Rupture: Insights From Genetic and Experimental Models. (Circulation)
Article 2: Left bundle branch area pacing vs right ventricular pacing for atrioventricular block: the MELOS RELOADED study. (European heart journal)
Article 3: Epidemiology and risk factors for constrictive pericarditis in a statewide Australian cohort of patients with pericardial disease. (The Canadian journal of cardiology)
Article 4: Self-Expanding Intra-Annular Transcatheter Aortic Valve Replacement System in Patients with Severely Calcified Aortic Valve. (The Canadian journal of cardiology)
Article 5: Lower interventricular septal thickness from computed tomography predicts the need for pacemaker implantation after TAVR. (International journal of cardiology)
Full episode page: https://podcast.explainheart.com/podcast/triglycerides-drive-aneurysm-rupture-risk-09-23-25/
Featured Articles
Article 1: Hypertriglyceridemia as a Key Contributor to Abdominal Aortic Aneurysm Development and Rupture: Insights From Genetic and Experimental Models.
Journal: Circulation
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40762097
Summary: This study used Mendelian randomization and experimental models to investigate the relationship between triglycerides and abdominal aortic aneurysm. The findings suggest elevated triglyceride levels causally contribute to abdominal aortic aneurysm development and rupture, identifying a potential therapeutic target. This indicates that lowering triglycerides could be a pharmacological strategy to prevent abdominal aortic aneurysm progression.
Article 2: Left bundle branch area pacing vs right ventricular pacing for atrioventricular block: the MELOS RELOADED study.
Journal: European heart journal
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40977097
Summary: The MELOS RELOADED study, a multicenter European registry, compared left bundle branch area pacing to right ventricular pacing in patients with atrioventricular block. Results demonstrated no significant difference in long-term survival between the two pacing strategies. Further analysis is needed to identify subgroups that may benefit more from left bundle branch area pacing.
Article 3: Epidemiology and risk factors for constrictive pericarditis in a statewide Australian cohort of patients with pericardial disease.
Journal: The Canadian journal of cardiology
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40983194
Summary: This retrospective cohort study analyzed hospitalized patients with pericardial disease in New South Wales, Australia, from 2004 to 2021 to identify risk factors for constrictive pericarditis. The study defined the epidemiology and predictors of constrictive pericarditis utilizing multivariable logistic regression to determine risk factors within this large population-based cohort. The results illuminate potential targets for early intervention and prevention of this rare but serious complication.
Article 4: Self-Expanding Intra-Annular Transcatheter Aortic Valve Replacement System in Patients with Severely Calcified Aortic Valve.
Journal: The Canadian journal of cardiology
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40983190
Summary: This retrospective, multicenter study evaluated the impact of severe aortic valve calcification on outcomes following transcatheter aortic valve replacement using self-expanding intra-annular transcatheter heart valves. The study revealed that severe aortic valve calcification does not significantly impact procedural or clinical outcomes in patients undergoing transcatheter aortic valve replacement with Portico or Navitor transcatheter heart valves. This suggests that these valves are safe and effective even in patients with heavily calcified valves.
Article 5: Lower interventricular septal thickness from computed tomography predicts the need for pacemaker implantation after TAVR.
Journal: International journal of cardiology
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40983185
Summary: This study investigated the role of interventricular septal thickness, measured via pre-procedural computed tomography, in predicting the need for permanent pacemaker implantation after transcatheter aortic valve replacement. The findings indicate that lower interventricular septal thickness is a predictor of permanent pacemaker implantation post-transcatheter aortic valve replacement. Integrating interventricular septal thickness into pre-procedural assessment may improve risk stratification and patient selection.
Transcript
Today’s date is September 23, 2025. Welcome to Cardiology Today. Here are the latest research findings.
Article number one. Hypertriglyceridemia as a Key Contributor to Abdominal Aortic Aneurysm Development and Rupture: Insights From Genetic and Experimental Models. This study used Mendelian randomization and experimental models to investigate the relationship between triglycerides and abdominal aortic aneurysm. The findings suggest elevated triglyceride levels causally contribute to abdominal aortic aneurysm development and rupture, identifying a potential therapeutic target. This indicates that lowering triglycerides could be a pharmacological strategy to prevent abdominal aortic aneurysm progression.
Article number two. Left bundle branch area pacing vs right ventricular pacing for atrioventricular block: the MELOS RELOADED study. The MELOS RELOADED study, a multicenter European registry, compared left bundle branch area pacing to right ventricular pacing in patients with atrioventricular block. Results demonstrated no significant difference in long-term survival between the two pacing strategies. Further analysis is needed to identify subgroups that may benefit more from left bundle branch area pacing.
Article number three. Epidemiology and risk factors for constrictive pericarditis in a statewide Australian cohort of patients with pericardial disease. This retrospective cohort study analyzed hospitalized patients with pericardial disease in New South Wales, Australia, from 2004 to 2021 to identify risk factors for constrictive pericarditis. The study defined the epidemiology and predictors of constrictive pericarditis utilizing multivariable logistic regression to determine risk factors within this large population-based cohort. The results illuminate potential targets for early intervention and prevention of this rare but serious complication.
Article number four. Self-Expanding Intra-Annular Transcatheter Aortic Valve Replacement System in Patients with Severely Calcified Aortic Valve. This retrospective, multicenter study evaluated the impact of severe aortic valve calcification on outcomes following transcatheter aortic valve replacement using self-expanding intra-annular transcatheter heart valves. The study revealed that severe aortic valve calcification does not significantly impact procedural or clinical outcomes in patients undergoing transcatheter aortic valve replacement with Portico or Navitor transcatheter heart valves. This suggests that these valves are safe and effective even in patients with heavily calcified valves.
Article number five. Lower interventricular septal thickness from computed tomography predicts the need for pacemaker implantation after TAVR. This study investigated the role of interventricular septal thickness, measured via pre-procedural computed tomography, in predicting the need for permanent pacemaker implantation after transcatheter aortic valve replacement. The findings indicate that lower interventricular septal thickness is a predictor of permanent pacemaker implantation post-transcatheter aortic valve replacement. Integrating interventricular septal thickness into pre-procedural assessment may improve risk stratification and patient selection.
Thank you for listening. Don’t forget to subscribe.
Keywords
MELOS RELOADED, Pacemaker, Left Bundle Branch Area Pacing, Navitor, Epidemiology, Aortic Valve Calcification, Atrioventricular Block, Portico, Computed Tomography, Right Ventricular Pacing, Abdominal Aortic Aneurysm, Hypertriglyceridemia, Self-Expanding Valve, Interventricular Septal Thickness, Transcatheter Aortic Valve Replacement, Permanent Pacemaker Implantation, Mendelian Randomization, Risk Factors, Constrictive Pericarditis, Lipoproteins, Aortic Stenosis, Pericardial Disease.
About
Concise summaries of cardiovascular research for professionals.
Subscribe • Share • FollowThe post Triglycerides Drive Aneurysm Rupture Risk 09/23/25 first appeared on Cardiology Today.
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