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Listen "Sex Differences in A.fib Remodeling Defined 09/26/25"
Episode Synopsis
Welcome to Cardiology Today – Recorded September 26, 2025. This episode summarizes 5 key cardiology studies on topics like vascular remodeling and atrial remodeling. Key takeaway: Sex Differences in A.fib Remodeling Defined.
Article Links:
Article 1: Clinical and Prognostic Significance of Anomalous Origin of a Coronary Artery in Adults. (Circulation)
Article 2: Screening-Detected Atrial Fibrillation and Cardiovascular Outcomes in Working-Age Adults. (Circulation)
Article 3: Sex differences in atrial fibrillation-related atrial remodelling assessed by electroanatomic mapping and biopsy. (European heart journal)
Article 4: EP4/ANXA2 axis in pulmonary arterial hypertension: therapeutic implications. (European heart journal)
Article 5: Abnormal electrocardiogram findings in athletes. (European heart journal)
Full episode page: https://podcast.explainheart.com/podcast/sex-differences-in-a-fib-remodeling-defined-09-26-25/
Featured Articles
Article 1: Clinical and Prognostic Significance of Anomalous Origin of a Coronary Artery in Adults.
Journal: Circulation
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40995628
Summary: This study analyzed the clinical implications of anomalous aortic origin of a coronary artery in adults using coronary computed tomography angiography. The study, conducted at an Italian center from 2004-2024, sought to determine outcome predictors. The results detail specific clinical outcomes, which will improve risk stratification for these patients.
Article 2: Screening-Detected Atrial Fibrillation and Cardiovascular Outcomes in Working-Age Adults.
Journal: Circulation
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40995626
Summary: This retrospective cohort study in Japan evaluated the incidence and cardiovascular outcomes of screening-detected atrial fibrillation in working-age adults. Mandatory E.C.G.s during annual health screenings provided a unique opportunity to identify atrial fibrillation early. The findings reveal the long-term cardiovascular risks associated with screening-detected atrial fibrillation in this population, highlighting the importance of early detection and intervention to prevent stroke and other complications.
Article 3: Sex differences in atrial fibrillation-related atrial remodelling assessed by electroanatomic mapping and biopsy.
Journal: European heart journal
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40996829
Summary: This study investigated sex differences in atrial structural remodeling in patients with non-valvular atrial fibrillation by performing right atrial biopsies and high-density voltage mapping. The research included 282 atrial fibrillation patients and 58 controls undergoing supraventricular tachycardia ablation. The results showed notable histopathological differences between men and women, providing insights into potential sex-specific atrial fibrillation mechanisms and treatment approaches.
Article 4: EP4/ANXA2 axis in pulmonary arterial hypertension: therapeutic implications.
Journal: European heart journal
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40996819
Summary: This research investigated the role of the prostaglandin E2 receptor E.P.4 in the pathogenesis of pulmonary arterial hypertension, a condition characterized by abnormal proliferation of pulmonary artery smooth muscle cells. The study aimed to evaluate the potential of E.P.4 as a therapeutic target for pulmonary arterial hypertension. The findings suggest that targeting E.P.4 could offer a novel therapeutic approach for managing pulmonary arterial hypertension by modulating the E.P.4/A.N.X.A.2 axis.
Article 5: Abnormal electrocardiogram findings in athletes.
Journal: European heart journal
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40996312
Summary: This article discusses the challenges in interpreting E.C.G.s in athletes, where physiological adaptations can mimic cardiac pathology. It highlights the ongoing efforts to differentiate benign E.C.G. changes from potentially pathological findings requiring further investigation. Addressing diagnostic uncertainties in cardiac assessment of athletes is crucial to avoid unnecessary restrictions and ensure appropriate management of true cardiac conditions.
Transcript
Today’s date is September 26, 2025. Welcome to Cardiology Today. Here are the latest research findings.
Article number one. Clinical and Prognostic Significance of Anomalous Origin of a Coronary Artery in Adults. This study analyzed the clinical implications of anomalous aortic origin of a coronary artery in adults using coronary computed tomography angiography. The study, conducted at an Italian center from 2004-2024, sought to determine outcome predictors. The results detail specific clinical outcomes, which will improve risk stratification for these patients.
Article number two. Screening-Detected Atrial Fibrillation and Cardiovascular Outcomes in Working-Age Adults. This retrospective cohort study in Japan evaluated the incidence and cardiovascular outcomes of screening-detected atrial fibrillation in working-age adults. Mandatory E.C.G.s during annual health screenings provided a unique opportunity to identify atrial fibrillation early. The findings reveal the long-term cardiovascular risks associated with screening-detected atrial fibrillation in this population, highlighting the importance of early detection and intervention to prevent stroke and other complications.
Article number three. Sex differences in atrial fibrillation-related atrial remodelling assessed by electroanatomic mapping and biopsy. This study investigated sex differences in atrial structural remodeling in patients with non-valvular atrial fibrillation by performing right atrial biopsies and high-density voltage mapping. The research included 282 atrial fibrillation patients and 58 controls undergoing supraventricular tachycardia ablation. The results showed notable histopathological differences between men and women, providing insights into potential sex-specific atrial fibrillation mechanisms and treatment approaches.
Article number four. EP4/ANXA2 axis in pulmonary arterial hypertension: therapeutic implications. This research investigated the role of the prostaglandin E2 receptor E.P.4 in the pathogenesis of pulmonary arterial hypertension, a condition characterized by abnormal proliferation of pulmonary artery smooth muscle cells. The study aimed to evaluate the potential of E.P.4 as a therapeutic target for pulmonary arterial hypertension. The findings suggest that targeting E.P.4 could offer a novel therapeutic approach for managing pulmonary arterial hypertension by modulating the E.P.4/A.N.X.A.2 axis.
Article number five. Abnormal electrocardiogram findings in athletes. This article discusses the challenges in interpreting E.C.G.s in athletes, where physiological adaptations can mimic cardiac pathology. It highlights the ongoing efforts to differentiate benign E.C.G. changes from potentially pathological findings requiring further investigation. Addressing diagnostic uncertainties in cardiac assessment of athletes is crucial to avoid unnecessary restrictions and ensure appropriate management of true cardiac conditions.
Thank you for listening. Don’t forget to subscribe.
Keywords
vascular remodeling, atrial remodeling, coronary artery disease, Anomalous aortic origin of a coronary artery, stroke prevention, right atrial biopsy, Pulmonary arterial hypertension, sex differences, cardiovascular outcomes, pulmonary artery smooth muscle cells, sudden cardiac death, prostaglandin E2, cardiac screening, electroanatomic mapping, Atrial fibrillation, Athlete’s heart, E.P.4 receptor, electrocardiogram, E.C.G. interpretation, coronary computed tomography angiography, working-age adults, E.C.G. screening.
About
Concise summaries of cardiovascular research for professionals.
Subscribe • Share • FollowThe post Sex Differences in A.fib Remodeling Defined 09/26/25 first appeared on Cardiology Today.
Article Links:
Article 1: Clinical and Prognostic Significance of Anomalous Origin of a Coronary Artery in Adults. (Circulation)
Article 2: Screening-Detected Atrial Fibrillation and Cardiovascular Outcomes in Working-Age Adults. (Circulation)
Article 3: Sex differences in atrial fibrillation-related atrial remodelling assessed by electroanatomic mapping and biopsy. (European heart journal)
Article 4: EP4/ANXA2 axis in pulmonary arterial hypertension: therapeutic implications. (European heart journal)
Article 5: Abnormal electrocardiogram findings in athletes. (European heart journal)
Full episode page: https://podcast.explainheart.com/podcast/sex-differences-in-a-fib-remodeling-defined-09-26-25/
Featured Articles
Article 1: Clinical and Prognostic Significance of Anomalous Origin of a Coronary Artery in Adults.
Journal: Circulation
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40995628
Summary: This study analyzed the clinical implications of anomalous aortic origin of a coronary artery in adults using coronary computed tomography angiography. The study, conducted at an Italian center from 2004-2024, sought to determine outcome predictors. The results detail specific clinical outcomes, which will improve risk stratification for these patients.
Article 2: Screening-Detected Atrial Fibrillation and Cardiovascular Outcomes in Working-Age Adults.
Journal: Circulation
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40995626
Summary: This retrospective cohort study in Japan evaluated the incidence and cardiovascular outcomes of screening-detected atrial fibrillation in working-age adults. Mandatory E.C.G.s during annual health screenings provided a unique opportunity to identify atrial fibrillation early. The findings reveal the long-term cardiovascular risks associated with screening-detected atrial fibrillation in this population, highlighting the importance of early detection and intervention to prevent stroke and other complications.
Article 3: Sex differences in atrial fibrillation-related atrial remodelling assessed by electroanatomic mapping and biopsy.
Journal: European heart journal
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40996829
Summary: This study investigated sex differences in atrial structural remodeling in patients with non-valvular atrial fibrillation by performing right atrial biopsies and high-density voltage mapping. The research included 282 atrial fibrillation patients and 58 controls undergoing supraventricular tachycardia ablation. The results showed notable histopathological differences between men and women, providing insights into potential sex-specific atrial fibrillation mechanisms and treatment approaches.
Article 4: EP4/ANXA2 axis in pulmonary arterial hypertension: therapeutic implications.
Journal: European heart journal
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40996819
Summary: This research investigated the role of the prostaglandin E2 receptor E.P.4 in the pathogenesis of pulmonary arterial hypertension, a condition characterized by abnormal proliferation of pulmonary artery smooth muscle cells. The study aimed to evaluate the potential of E.P.4 as a therapeutic target for pulmonary arterial hypertension. The findings suggest that targeting E.P.4 could offer a novel therapeutic approach for managing pulmonary arterial hypertension by modulating the E.P.4/A.N.X.A.2 axis.
Article 5: Abnormal electrocardiogram findings in athletes.
Journal: European heart journal
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40996312
Summary: This article discusses the challenges in interpreting E.C.G.s in athletes, where physiological adaptations can mimic cardiac pathology. It highlights the ongoing efforts to differentiate benign E.C.G. changes from potentially pathological findings requiring further investigation. Addressing diagnostic uncertainties in cardiac assessment of athletes is crucial to avoid unnecessary restrictions and ensure appropriate management of true cardiac conditions.
Transcript
Today’s date is September 26, 2025. Welcome to Cardiology Today. Here are the latest research findings.
Article number one. Clinical and Prognostic Significance of Anomalous Origin of a Coronary Artery in Adults. This study analyzed the clinical implications of anomalous aortic origin of a coronary artery in adults using coronary computed tomography angiography. The study, conducted at an Italian center from 2004-2024, sought to determine outcome predictors. The results detail specific clinical outcomes, which will improve risk stratification for these patients.
Article number two. Screening-Detected Atrial Fibrillation and Cardiovascular Outcomes in Working-Age Adults. This retrospective cohort study in Japan evaluated the incidence and cardiovascular outcomes of screening-detected atrial fibrillation in working-age adults. Mandatory E.C.G.s during annual health screenings provided a unique opportunity to identify atrial fibrillation early. The findings reveal the long-term cardiovascular risks associated with screening-detected atrial fibrillation in this population, highlighting the importance of early detection and intervention to prevent stroke and other complications.
Article number three. Sex differences in atrial fibrillation-related atrial remodelling assessed by electroanatomic mapping and biopsy. This study investigated sex differences in atrial structural remodeling in patients with non-valvular atrial fibrillation by performing right atrial biopsies and high-density voltage mapping. The research included 282 atrial fibrillation patients and 58 controls undergoing supraventricular tachycardia ablation. The results showed notable histopathological differences between men and women, providing insights into potential sex-specific atrial fibrillation mechanisms and treatment approaches.
Article number four. EP4/ANXA2 axis in pulmonary arterial hypertension: therapeutic implications. This research investigated the role of the prostaglandin E2 receptor E.P.4 in the pathogenesis of pulmonary arterial hypertension, a condition characterized by abnormal proliferation of pulmonary artery smooth muscle cells. The study aimed to evaluate the potential of E.P.4 as a therapeutic target for pulmonary arterial hypertension. The findings suggest that targeting E.P.4 could offer a novel therapeutic approach for managing pulmonary arterial hypertension by modulating the E.P.4/A.N.X.A.2 axis.
Article number five. Abnormal electrocardiogram findings in athletes. This article discusses the challenges in interpreting E.C.G.s in athletes, where physiological adaptations can mimic cardiac pathology. It highlights the ongoing efforts to differentiate benign E.C.G. changes from potentially pathological findings requiring further investigation. Addressing diagnostic uncertainties in cardiac assessment of athletes is crucial to avoid unnecessary restrictions and ensure appropriate management of true cardiac conditions.
Thank you for listening. Don’t forget to subscribe.
Keywords
vascular remodeling, atrial remodeling, coronary artery disease, Anomalous aortic origin of a coronary artery, stroke prevention, right atrial biopsy, Pulmonary arterial hypertension, sex differences, cardiovascular outcomes, pulmonary artery smooth muscle cells, sudden cardiac death, prostaglandin E2, cardiac screening, electroanatomic mapping, Atrial fibrillation, Athlete’s heart, E.P.4 receptor, electrocardiogram, E.C.G. interpretation, coronary computed tomography angiography, working-age adults, E.C.G. screening.
About
Concise summaries of cardiovascular research for professionals.
Subscribe • Share • FollowThe post Sex Differences in A.fib Remodeling Defined 09/26/25 first appeared on Cardiology Today.
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