Send us a text🧠 Clinical Problem:Behavioral disturbances in Alzheimer’s are notoriously hard to treat.Guidelines tell us: “Don’t use antipsychotics” — but what do you do at 2AM when Nana's throwing punches?💊 Study Overview:345 patients, moderate-severe Alzheimer’s + aggressive agitation.Brexpiprazole 2–3 mg daily vs placebo.Dosing didn’t differ much in effect.📈 Outcomes:Significant reduction in agitation inventory scores in brexpiprazole group.Well tolerated; most common side effect: headache (7%).⚠️ Caveats:Costly medication.Atypical antipsychotic — still carries black box warning for mortality in dementia.🧩 Clinical Takeaway:Brexpiprazole may offer a much-needed option in patients with severe behavioral disturbances.Not for mild sundowning — reserve for safety-critical scenarios.Discuss risks/benefits carefully with family or POA.

Ver todos los episodios