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Listen "🎙️ Episode 24: Pretreat or Nah? P2Y12s in NSTEMI Under Fire"
Episode Synopsis
Send us a text🧠 Historical practice:Pre-load clopidogrel (or ticagrelor) before cath.Rationale: reduce thrombotic burden prior to PCI.🧪 New Data:Large observational study: 100k+ NSTEMI patients.No benefit in MI or death with pretreatment.Longer LOS, delayed CABG in pre-treated patients.🧩 Clinical Takeaway:Defer P2Y12 until coronary anatomy is known — especially if CABG is on the table.If PCI is clearly planned and delay expected — preloading may still be reasonable.
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