Send us a text🧠 Clinical Question:Are we overtreating bloodstream infections with 14-day regimens?🧪 Study Overview:Multicenter RCT in ICU/inpatient settings (7 vs 14 days of antibiotics).Excluded: Immunosuppressed, endocarditis, Staph aureus, and infections needing longer therapy.📈 Findings:No difference in 90-day mortality or relapse.More C. diff and drug reactions in the 14-day group.🧩 Clinical Pearls:7 days is sufficient for most uncomplicated bacteremia.Reserve 14+ days for Staph aureus, endocarditis, or deep-seated infections.Fewer days = lower risk, lower cost, faster discharge.

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