Factor XIII (13), Fibrinolysis & Thrombolysis

12/07/2025 46 min Temporada 2 Episodio 8
Factor XIII (13), Fibrinolysis & Thrombolysis

Listen "Factor XIII (13), Fibrinolysis & Thrombolysis "

Episode Synopsis

Feedback01:45 Case: Neonate with repeated umblical bleeding. IC haemorrhage.  Normal Factors (so far), Normal VW screen, Normal FBC and normal film.05:35 Factor XIII (13): function and presentations in deficiency 09:45 Testing, testing! ELISA/Ammonia Release Assay then a Mutational Analysis Honarable mention: Clot Solubility Assay16:00 Fibrinolysis definition and pathway21:00 Activators of Fibrinolysis: tPA vs. uPA 23:23 Inhibitors of Fibrinolysis: PAI-1, PAI-2, TAFI, α2-antiplasmin, and Factor XIII (13)26:28 Thrombolysis: defintion, examples and uses32:20 Case: Thromboembolic stroke, thrombolysis 24 hours prior, haemorrhagic transformation36:19: Tranexamic Acid (Hari’s favourite drug)Honarable mention: Dr Utako Okamoto and the WOMAN trialCRASH 2 and CRASH 3 trialsHALT-IT trial41:22 D-Dimer 44:00 Summary 'Basics to Brilliance: Haematology Podcast' has been accredited for CPD credit by the Royal College of Pathologists UK. Medical professionals and clinical scientists holding career-grade positions, who are registered with any of the Royal Colleges for CPD, will be eligible to earn 1 credit for every hour of learning. Email: [email protected] Insta: BasicstoBrilliance X: @basics_2_brill Send us your feedback!