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Listen "The pyridoxal phosphate contribution to amino acid metabolism and neurotransmitter turnover Dr Guerra Authentic Biochemistry 10 March 2021"
Episode Synopsis
If γ-aminobutyric acid (GABA) concentration drops significantly in the synaptic cleft, excitotoxicity can obtain, sometimes presenting with epileptic convulsions.This can be reversed by decreasing the concentration of L-glutamate via control over the activity of glutamate dehydrogenase, glutamine synthetase and glutamate transporters or by the inhibition of γ-aminobutyric acid aminotransferase (GABA-AT), which catalyzes the conversion of GABA to the excitatory neurotransmitter l-glutamic acid.
Trends in Cell Biology 2020. 30.6: 440-451.
Chem. Rev. 2018. 118. 7: 4037–4070
Trends in Cell Biology 2020. 30.6: 440-451.
Chem. Rev. 2018. 118. 7: 4037–4070
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