Listen "ASH 2021: a deep dive into ALL immunotherapy"
Episode Synopsis
Various forms of immunotherapy represent a novel treatment option, especially for patients who progress from conventional chemotherapy hematopoietic stem-cell transplantation (HSCT). Chimeric antigen receptor (CAR) T-cell therapy consists of modified T cells from patients that target antigens specific to cancer cells. Six CAR T-cell therapies have currently been approved by the FDA, with tisagenlecleucel and brexucabtagene autoleucel approved for B-cell acute lymphoblastic leukemia (B-ALL).
Tune into this podcase as Nitin Jain, MD, University of Texas MD Anderson Cancer Center, Houston, TX, delves into the latest updates in CAR T-cell therapies for B-ALL, including exciting results from the Phase I BALLI-01 trial (NCT04150497) of UCART22 and a Phase I/IIa trial of PBCAR0191 (NCT03666000). Dr Jain additionally presents preliminary results from a Phase I/II trial of ADCT-602 (NCT03698552), an antibody drug conjugate composed of an anti-CD22 antibody and a pyrrolobenzodiazepine (PBD) dimer cytotoxin. This interview took place at the 63rd ASH Annual Meeting and Exposition Congress, Atlanta, GA, 2021.
Tune into this podcase as Nitin Jain, MD, University of Texas MD Anderson Cancer Center, Houston, TX, delves into the latest updates in CAR T-cell therapies for B-ALL, including exciting results from the Phase I BALLI-01 trial (NCT04150497) of UCART22 and a Phase I/IIa trial of PBCAR0191 (NCT03666000). Dr Jain additionally presents preliminary results from a Phase I/II trial of ADCT-602 (NCT03698552), an antibody drug conjugate composed of an anti-CD22 antibody and a pyrrolobenzodiazepine (PBD) dimer cytotoxin. This interview took place at the 63rd ASH Annual Meeting and Exposition Congress, Atlanta, GA, 2021.
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