Featuring a slide presentation and related discussion from Dr Alexander Spira, including the following topics: Incidence and spectrum of KRAS mutations in non-small cell lung cancer (NSCLC) (0:00) Sotorasib for the treatment of NSCLC with a KRAS G12C mutation (2:06) Clinical data evaluating adagrasib for the treatment of NSCLC with a KRAS G12C mutation (9:44) Future directions in the care of patients with NSCLC with KRAS mutations (22:17) Case: A man in his early 70s with relapsed NSCLC with a G12C mutation (26:26) Case: A man in his mid 60s with newly diagnosed metastatic NSCLC with a KRAS G12C mutation (27:53) CME information and select publications

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