In this episode of the Research Digest Podcast, we discussedthe article titled “Dynamic Changes in Heparan Sulfate Nanostructure in Human Pluripotent Stem Cell Differentiation”, published in ACS Nano (2023). We spoke with the lead author, Dr. Deena Al Mahbuba, about the background of the research work, its major findings, and future perspectives.THIS EPISODE on YOUTUBEhttps://youtu.be/rtVNZWDLmtU ARTICLE LINK https://pubs.acs.org/doi/full/10.1021/acsnano.2c10072TIMESTAMPS 00:00 – Introduction01:20 – Career journey of the author04:45 – Introducing the author05:30 – Starting the project and the knowledge gap11:30 – Heparan sulfate proteoglycans and their importance15:40 – Expansion microscopy22:00 – Major findings and observations32:00 – Role of heparan sulfate in the fate decision of hematopoietic stem cells38:20 – Challenges of the project43:40 – Message to the young scientists

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