This excerpt comes from a review of the book Early Detection, a work written by Bruce Ratner and Adam Bonislawski that advocates for a shift in cancer care from primarily focusing on treatment to emphasizing early detection. The review, penned by Gitte Pedersen, highlights the book's central argument that early detection holds immense potential for significantly reducing cancer mortality. The excerpt emphasizes the economic and societal benefits of early detection, citing research demonstrating the life-years gained and the potential for significant cost savings. The text criticizes the current healthcare system's underfunding of early detection research and the widespread use of expensive treatments that often fail to produce long-term survival benefits. It underscores the importance of developing new screening tests and diagnostics that can accurately identify high-risk individuals, improve treatment outcomes, and reduce the burden of false positives. The review concludes with Pedersen's personal perspective as a biotech entrepreneur, emphasizing the need for collaboration among government, payors, regulators, and the biotech industry to address the shortcomings of the current paradigm and drive positive change in cancer care.Key TopicsEarly cancer detectionEconomic benefitsCancer mortalityScreening guidelinesPan-cancer screening

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