Distinguishing First-Line Treatment Adverse Event Profiles in HER2-Negative Upper GI Cancers

30/09/2025 4 min

Listen "Distinguishing First-Line Treatment Adverse Event Profiles in HER2-Negative Upper GI Cancers "

Episode Synopsis

CME credits: 0.50
Valid until: 30-09-2026
Claim your CME credit at https://reachmd.com/programs/cme/distinguishing-first-line-treatment-adverse-event-profiles-in-her2-negative-upper-gi-cancers/37691/



This activity examines first-line treatment strategies for advanced HER2-negative upper gastrointestinal cancers. Expert commentary highlights the role of biomarker testing, including PD-L1 CPS and CLDN18.2, in guiding therapeutic decisions. Key clinical trial data on anti-PD-1 therapies such as nivolumab, pembrolizumab, and tislelizumab are discussed, along with regimen-specific adverse event profiles. Patient case examples illustrate the application of guideline-based treatment selection utilizing biomarker status in clinical practice.

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