Welcome back to Rad Onc Smart Review! This is Episode 37: G2/M Control (Wee1) & Apoptosis (Bcl-2/Caspases). In our previous episode, we explored the intricate mechanisms of G1/S checkpoint control, highlighting the roles of p53, p21, and the Rb/E2F pathway. Today, we shift our focus to another critical regulatory point, the G2/M transition, and then delve into the fascinating and highly regulated process of programmed cell death, or apoptosis. We'll examine how Wee1 kinase and Cdc25 phosphatases govern entry into mitosis, and then explore both the intrinsic (mitochondrial) and extrinsic (death receptor) pathways of apoptosis, paying close attention to the Bcl-2 family of proteins and the caspase cascade. Understanding these pathways is fundamental to grasping how cells respond to damage and how cancer cells often evade these critical controls.

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