This is Episode 13 Part C, Cancer Biology - Signaling: EGFR, Ras, PI3K, Myc, and NF-κB.In our previous episodes on cancer biology, we've explored oncogenes – the cellular accelerators – and tumor suppressor genes – the cellular brakes. Today, we're going to connect these concepts by diving into the intricate communication networks within cells: the signaling pathways. These pathways dictate how cells respond to their environment, when to grow, when to divide, and when to die. We'll focus on some of the most important signaling pathways frequently dysregulated in cancer and highly relevant to radiation response, including the EGFR, Ras/MAPK, and PI3K/Akt pathways, and then look at the powerful downstream transcription factors Myc and NF-kappaB.

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