Welcome back to Rad Onc Smart Review, the podcast dedicated to helping you master the core concepts of radiation oncology and radiobiology. This is Episode 13 Part B, Cancer Biology - Tumor Suppressor Genes .In our previous episode, we delved into the world of oncogenes, the "gas pedals" of the cell that, when stuck, can drive cancer. Today, we're turning our attention to the other side of the coin: Tumor Suppressor Genes, or TSGs. These are the "brakes" of the cell, crucial for keeping cell growth in check and maintaining the integrity of our genome. We'll explore what happens when these brakes fail, the classic "two-hit hypothesis" that explains their inactivation, and look at some key examples like RB1, TP53, and BRCA1/2.

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