This is Episode 03: Esophagus Part 2: Neoadjuvant & Definitive CCRT.In our last episode, we laid the groundwork for esophageal cancer management. Now, we move to the heart of the matter: how we treat locally advanced disease. This episode is all about the landmark trials that defined the role of chemoradiation. We'll dissect the two pillars of modern esophageal radiation oncology: RTOG eighty-five-zero-one for definitive treatment, and the CROSS trial for the neoadjuvant setting. We’ll then see how these standards are being challenged by newer chemotherapy regimens.

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