The source provides a comprehensive review of the dramatic shift occurring in prostate cancer diagnosis, moving away from the unreliable "blind" transrectal ultrasound-guided systematic biopsy. The primary catalyst for this change is the adoption of multiparametric MRI (mpMRI), which utilizes advanced imaging techniques and the PI-RADS scoring system to accurately visualize and locate tumors, thereby minimizing both infection risk and the over-diagnosis of harmless cancers. Major clinical trials have confirmed that an mpMRI-first strategy significantly increases the detection of clinically aggressive disease while reducing the necessity of initial biopsy for many men. While complete replacement is not yet universal, due to the occasional false negative and the need for definitive tissue confirmation before radical therapy, mpMRI’s high negative predictive value already allows many low-risk patients to safely avoid the procedure. Ultimately, the text predicts that traditional sampling will soon be replaced by targeted biopsies guided by MRI or micro-ultrasound, or through imaging-only monitoring, fundamentally modernizing diagnostic pathways.

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