Beyond Lithium Monotherapy: Evidence-Based Augmentation in Acute Mania

22/11/2025 7 min
Beyond Lithium Monotherapy: Evidence-Based Augmentation in Acute Mania

Listen "Beyond Lithium Monotherapy: Evidence-Based Augmentation in Acute Mania"

Episode Synopsis

In this episode, we explore evidence-based strategies for augmenting lithium when monotherapy fails in acute mania. Why is quetiapine the preferred add-on to valproate, despite decades of clinical tradition favoring anticonvulsants? Faculty: David Osser, M.D. Host: Richard Seeber, M.D. Learn more about our memberships here Earn 1.25 CME: An Update on Bipolar Mania Algorithm Augmenting With SGAs After Unsatisfactory Response to Lithium in Bipolar Mania