How could a single psychedelic treatment cause lasting change? Joshua Siegel, MD, PhD, is on a mission to find out. A leading expert on neuroimaging and neuropsychopharmacology at NYU Langone’s Center for Psychedelic Medicine, Dr. Siegel unpacks how psilocybin may spark neuroplasticity and reshape the depressed brain. He also gives us an inside look at the race to develop non-hallucinogenic psychedelic analogs. Dr. Siegel is an assistant professor at NYU Grossman School of Medicine.🔍 Topics Covered:00:00 Introduction00:15 Dr. Siegel's Current Work01:01 Past Research and Human Psilocybin Imaging Study02:39 Understanding Brain Changes and Biomarkers06:13 Mechanisms of Action and Plasticity12:51 Surprising Findings and Context Dependence16:34 Challenges and Future Directions in Psychedelic Research20:46 Advanced Imaging and Personalized Treatment Plans24:15 Setbacks and Lessons in Psychedelic Medicine28:40 Emerging Areas in Neuropsychopharmacology31:46 Conclusion📚 Related Resources:Joshua Siegel, MD, PhD  NYU Langone Health’s Center for Psychedelic MedicineThe Multidisciplinary Association for Psychedelic Studies (MAPS)“Psychedelic and Dissociative Drugs as Medicines” (NIH) 🙌 Support & Engage: Enjoyed this episode? Like, comment, and share to support science-based conversations about mental health.🔔 Don’t forget to subscribe for more interviews with top psychiatric researchers.Visit our website for more Insights on Psychiatry.Watch this episode on YouTubeExecutive Producer: Jon Earle

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