This week's Editor’s Page outlines JACC’s expectations for AI research manuscripts in cardiovascular care, emphasizing the need for clinical relevance, real-world feasibility, and responsible evaluation beyond retrospective model performance. We present a framework focusing on three core domains: addressing a genuine clinical need, using fit-for-purpose evaluation methods across different development stages, and ensuring transparency, interpretability, and reproducibility. JACC prioritizes submissions that demonstrate real-world impact, responsible innovation, and a clear path to improving patient care—especially those that go beyond early model development.

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