In Acts 16:6-10, Paul and Silas and company travel through Galatia and Phrygia having been kept from preaching in the Roman province of Asia (In Asia were places like Colossae, Ephesus, Thyatira, and others) by the Holy Spirit. They come to the border of another place Bithynia and are denied entry by the Spirit here described as the Spirit of Jesus. There being no difference between the Holy Spirit and the Spirit of Jesus. So they go to another place (to catch themselves) and while there, Paul has a vision of a man from Macedonia begging him to come there and help them. After that vision, Luke says they got ready at once because they believed God had called them to go and preach the gospel to the Macedonians. 
We see here that they are denied entry into some places and called to another. It shows that God was guiding them and they obeyed his leading. Not knowing why, but obeying.
Do not despise closed doors, but embrace them. God is keeping you safe. Or perhaps you have some more growing to do before you can go through the open door. God knows. 
 
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