In this podcast, we discuss the paper "Cluster analysis tests the importance of myogenic gene expression during myofiber hypertrophy in humans" by Bamman et al. (2007), PMID: 17395765.

To our knowledge, this was the first study to explore potential molecular pathways that differentiate between non-, modest, and high-responders to hypertrophy from resistance training. We delve into the study design and methods, and key findings on how gene expression, including IGF-IEa, mechano-growth factor (MGF), and myogenin, impacts muscle adaptation.

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