The immune clock starts earlier than we think ⏳🧬   A landmark Nature study shows that immune aging begins quietly in midlife — decades before clinical frailty.   Using >16M single-cell profiles and longitudinal vaccine responses, researchers found: • Stable, early transcriptional drift in naïve & memory T cells • A subtle TH2 shift that may weaken antiviral antibody quality • Reduced IgG class-switching to repeat flu antigens (e.g., B/Phuket) • No acceleration from CMV infection despite compositional shifts   The message? Immune aging is gradual, not abrupt — and midlife may be the window for intervention.   Precision immunology will increasingly mean precision geroscience.

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